Anticholinergic drugs are associated with a 50% increase in the chances of dementia

PUBLISHED BY
Christy Gren



TAGS:


2 years ago




Commonly prescribed drugs like anti-depressants and anti-allergies are found to increase the chances of Dementia by 50%. Common drugs risk of Dementia includes Anticholinergic meds that are frequently prescribed for a wide range of diseases.  

common drugs risk

Anticholinergic drugs are prescribed by doctors for a wide range of illnesses – depression, allergies, and gastrointestinal disorders. Medicines from Benadryl to the ones prescribed for Parkinson’s disease fall in the category of Anticholinergic drugs. Anticholinergic drugs help to contract and relax muscles. They work by blocking acetylcholine, a chemical that transmits messages in the nervous system.

A new study conducted by experts from the University of Nottingham and funded by the National Institute for Health Research (NIHR), found that there was nearly a 50% increased risk of Dementia among patients aged 55 and over who had used strong anticholinergic medication daily for three years or more.

 “The study is important because it strengthens a growing body of evidence showing that strong anticholinergic drugs have long term associations with dementia risk,” said study author Carol Coupland, professor of medical statistics in primary care at the University of Nottingham.

For the study, the team of researchers, led by Carol Coupland looked at the medical records of 58,769 patients with a diagnosis of dementia and 225,574 patients without Dementia, all aged 55 and over. Each person with Dementia was matched to five control patients of the same age, sex, and general practice.

The study found that in the first ten years before the diagnosis of Dementia, 57 percent of Dementia cases and 51 percent of controlled patients were prescribed anticholinergic drugs. They found antidepressants, anti-vertigo, and bladder antimuscarinic drugs to be the most frequently prescribed drugs. The common drugs risk associated with anticholinergic drugs indicates that 10 percent of Dementia cases can be attributed to anticholinergic drug exposure. That is around 20,000 of the 209,600 new cases of dementia per year in the UK. Associations were stronger in cases diagnosed before 80 years and in cases diagnosed with Vascular Dementia rather than with Alzheimer’s disease.

The study pointed out that since common drugs risk of Dementia has a stronger association with Vascular Dementia, the mechanism through which such anticholinergic drugs increase the chances of Dementia, should be looked further since this association involves reasons much more than just the blocking of acetylcholine.

Professor Martin Rossor, NIHR National Director of Dementia Research, said: “This study gives insight into the potential long term impacts of the use of anticholinergic drugs. Further research is needed to confirm whether or not the association between these drugs and risk of dementia is causal. These drugs are prescribed for a number of health conditions and any concerns patients might have about them should be discussed with their doctors.”

Christy Gren
Christy Gren is an Industry Specialist Reporter at Industry Leaders Magazine she enjoys writing about Unicorns, Silicon Valley, Startups, Business Leaders and Innovators. Her articles provide an insight about the Power Players in the field of Technology, Auto, Manufacturing, and F&B.

Recent Posts

Elon Musk’s Starlink satellite internet set to cover the globe soon

Elon Musk’s Starlink satellite internet set to cover the globe soon

Starlink, the satellite internet unit of Elon Musk’s SpaceX, will most likely be able to provide global coverage by September, according to the company’s president Gwynne S
22 mins ago
At the next Krispy Kreme IPO, the donut maker aims to raise nearly $4 billion

At the next Krispy Kreme IPO, the donut maker aims to raise nearly $4 billion

Krispy Kreme, the popular donut chain, aims raise roughly $4 billion as it makes one of the biggest IPO debuts at the NYSE.
1 hour ago
Panasonic hopes Blue Yonder acquisition will improve its software woes

Panasonic hopes Blue Yonder acquisition will improve its software woes

Most Japanese major companies, which at one time were leaders in consumer electronics, are struggling to find their feet in a world that has moved to digital software. Electronics
18 hours ago
Ikea and Rockefeller Foundations to raise $10 billion for renewable energy projects in poor countries

Ikea and Rockefeller Foundations to raise $10 billion for renewable energy projects in poor countries

The Ikea and Rockefeller foundations are jointly launching a $10 billion fund to promote small-scale renewable power projects in developing nations. Both
2 days ago
EC initiates another probe into Google’s adtech practices

EC initiates another probe into Google’s adtech practices

EU antitrust regulators are planning a formal investigation into Google’s digital advertising practices by the end of this year. Google is already facing unprecedented regulatory
2 days ago
Some Microsoft employees stayed at data centers during Pandemic to keep all systems going

Some Microsoft employees stayed at data centers during Pandemic to keep all systems going

The Covid-19 pandemic ravaging the world for more than a year has forced companies and organizations to find viable solutions to keep the business going. Most found a solution in w
3 days ago